About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Ezetimibe selectively inhibits NPC1L1 (NiemannPick C1like 1) transporter in intestinal enterocytes, reducing absorption of dietary and biliary cholesterol. This lowers hepatic cholesterol influx and upregulates LDLreceptor expression.
Benefits and Advantages
Used in lipidtransport research, cholesterolhomeostasis modelling, NPC1L1 pathway assays, and LDLreduction mechanism studies.
Side Effects and Risks
Risks include GI discomfort, myalgia (especially with statins), elevated liver enzymes and fatigue. Handle with lipidmodulating agent precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C24H21F2NO3 |
|---|---|
| Molecular Weight | 409.4 g/mol |
| CAS Number | 163222-33-1 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Practically insoluble |
| Purity | Purity information is available upon request (COA). |
| Synonym | Ezetimibe; 163222-33-1; Zetia; Ezetrol; Ezedoc |
| IUPAC/Chemical Name | (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one |
| InChl Key | OLNTVTPDXPETLC-XPWALMASSA-N |
| InChl Code | InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1 |
| References |
3D Conformer.
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