FAMCICLOVIR
Famciclovir is an antiviral prodrug of penciclovir inhibiting herpesvirus replication. Side effects include headache, nausea, and fatigue. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Famciclovir is the oral prodrug of penciclovir. After absorption, it is converted to penciclovirtriphosphate, which inhibits viral DNA polymerase and terminates elongation in herpesvirus replication.
Benefits and Advantages
Used in herpesvirus replication modelling, nucleosideanalog activation studies, DNApolymerase inhibition assays, and antiviraldrug SAR analysis.
Side Effects and Risks
Risks include headache, nausea, liver enzyme elevation and rare hypersensitivity. Handle with antiviralnucleoside precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C14H19N5O4 |
|---|---|
| Molecular Weight | 321.33 g/mol |
| CAS Number | 104227-87-4 |
| Storage Condition | Store Famvir at room temperature between 59 deg and 86 °F (15 deg to 30 °C). |
| Solubility | Solubility in water (25 °C): > 25% w/v initially; rapidly precipitates as sparingly soluble monohydrate (2-3% w/v) |
| Purity | Purity information is available upon request (COA). |
| Synonym | famciclovir; 104227-87-4; Famvir; BRL-42810; Famciclovirum |
| IUPAC/Chemical Name | [2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate |
| InChl Key | GGXKWVWZWMLJEH-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18) |
| References |
3D Conformer.
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