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Product Description
Mechanism of Action
Etoposide phosphate is a water‑soluble prodrug of etoposide that is rapidly dephosphorylated in vivo. It improves formulation flexibility and reduces infusion‑related reactions compared with standard etoposide.
Benefits and Advantages
Used in prodrug‑conversion studies, aqueous‑formulation development, topoisomerase‑II research, and cancer‑cell cytotoxicity assays.
Side Effects and Risks
Risks include myelosuppression, infusion‑site irritation, hypotension and alopecia. Handle with cytotoxic‑prodrug precautions.
Datasheet
| Molecular Formula | C29H33O16P |
|---|---|
| Molecular Weight | 668.5 g/mol |
| CAS Number | 117091-64-2 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | ETOPOSIDE PHOSPHATE; 117091-64-2; Etopofos; Etopophos; BMY-40481 |
| IUPAC/Chemical Name | [4-[(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-9-yl]-2,6-dimethoxyphenyl] dihydrogen phosphate |
| InChl Key | LIQODXNTTZAGID-OCBXBXKTSA-N |
| InChl Code | InChI=1S/C29H33O16P/c1-11-38-9-20-27(42-11)23(30)24(31)29(43-20)44-25-14-7-17-16(40-10-41-17)6-13(14)21(22-15(25)8-39-28(22)32)12-4-18(36-2)26(19(5-12)37-3)45-46(33,34)35/h4-7,11,15,20-25,27,29-31H,8-10H2,1-3H3,(H2,33,34,35)/t11-,15+,20-,21-,22+,23-,24-,25-,27-,29+/m1/s1 |
| References |
3D Conformer.
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