About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Estropipate is a stabilized form of estrone in which estrone is complexed with piperazine sulfate to improve oral stability and absorption. After administration, the complex dissociates to release free estrone, which is converted intracellularly into estradiol and activates ER and ER. Through estrogenreceptor signalling, it regulates gene transcription in reproductive, skeletal, vascular and metabolic tissues.
Benefits and Advantages
Used in estrogenreplacement modelling, ERactivation assays, endocrineaxis research, bonemetabolism studies and hormonepharmacokinetics investigations.
Side Effects and Risks
Risks include thromboembolism, nausea, breast tenderness, fluid retention and hepatic stimulation. Handle with estrogencomplex precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C23H30O6 |
|---|---|
| Molecular Weight | 436.6 g/mol |
| CAS Number | 7280-37-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | less than 1 mg/mL at 70 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | Estropipate; 7280-37-7; Piperazine estrone sulfate; Ogen; Sulestrex |
| IUPAC/Chemical Name | [(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate;piperazine |
| InChl Key | HZEQBCVBILBTEP-ZFINNJDLSA-N |
| InChl Code | InChI=1S/C18H22O5S.C4H10N2/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;1-2-6-4-3-5-1/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);5-6H,1-4H2/t14-,15-,16+,18+;/m1./s1 |
| References |
3D Conformer.
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