ETHINYLESTRADIOL
Ethinylestradiol is a synthetic estrogen used in hormonal contraception and replacement therapy. It regulates ovulation and stabilizes the endometrium. Side effects include nausea, breast tenderness, and increased thromboembolic risk. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Ethinylestradiol is a potent synthetic estrogen with high oral bioavailability due to its ethinyl group, which prevents extensive firstpass metabolism. It activates ER/ER and regulates gene expression relevant to reproductive physiology, hepatic protein synthesis and metabolic pathways.
Benefits and Advantages
Used in hormonalcontraception research, estrogenreceptor signalling studies, PK/PD hormone modelling, and endocrinedisruption assays.
Side Effects and Risks
Risks include thromboembolism, hypertension, nausea, hepatic effects and hormonal imbalance. Handle with highpotency estrogen precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C20H24O2 |
|---|---|
| Molecular Weight | 296.4 g/mol |
| CAS Number | 57-63-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | less than 1 mg/mL at 70 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | ethinyl estradiol; 57-63-6; Ethynylestradiol; ETHINYLESTRADIOL; Ethynyl estradiol |
| IUPAC/Chemical Name | (8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol |
| InChl Key | BFPYWIDHMRZLRN-SLHNCBLASA-N |
| InChl Code | InChI=1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1 |
| References |
3D Conformer.
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