ERYTHROMYCIN THIOCYANATE

Erythromycin thiocyanate is a macrolide salt form with antimicrobial activity against grampositive organisms. Side effects include GI irritation, allergic reactions, and mild abdominal pain. Only GMP materials will be supplied, logistics all according to GDP.

SKU: 32980f0c41ad Category: Tag:

Product Description


Mechanism of Action

Erythromycin thiocyanate is a salt form providing improved stability and occasionally enhanced antimicrobial potency. Mechanism remains binding to 50S ribosomal exit tunnel to inhibit bacterial protein synthesis.

Benefits and Advantages

Used in saltform comparison research, macrolidestability studies, ribosomalaffinity assays, and antimicrobialactivity profiling.

Side Effects and Risks

Risks include GI symptoms, liverenzyme alterations and rare cardiotoxicity. Handle with macrolidesalt safety procedures.

Only GMP materials will be supplied, logistics all according to GDP.

Datasheet


Molecular Formula

C38H68N2O13S

Molecular Weight

793.0 g/mol

CAS Number

7704-67-8

Storage Condition

Commercially available erythromycin topical solutions and gels should be stored at 15 – 30 °C; exposure to heat or open flames should be avoided. The topical ointment should be stored at a temperature less than 27 °C.

Solubility

Soluble in water at 2mg/ml

Purity

Purity information is available upon request (COA).

Synonym

Erythromycin thiocyanate; 7704-67-8; Erythromycin, thiocyanate (salt); ERYTROVET; Y7A95YRI88

IUPAC/Chemical Name

(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione;thiocyanic acid

InChl Key

WVRRTEYLDPNZHR-YZPBMOCRSA-N

InChl Code

InChI=1S/C37H67NO13.CHNS/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26;2-1-3/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3;3H/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-;/m1./s1

References

https://pubchem.ncbi.nlm.nih.gov/compound/83938;

3D Conformer.

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