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Product Description
Mechanism of Action
Eprinomectin is a macrocyclic lactone endectocide of the avermectin family. It binds with high affinity to glutamategated chloride channels and, to a lesser extent, GABAgated channels in invertebrate nerve and muscle cells, causing chloride influx, hyperpolarization, paralysis and death of parasites. Its high lipophilicity and low milkresidue profile make it suited for veterinary use in lactating animals.
Benefits and Advantages
Used in endectocidemechanism research, parasite neuromuscular signalling studies, macrocycliclactone SAR analysis, and veterinary pharmacokinetic modelling.
Side Effects and Risks
Risks include neurotoxicity in sensitive species (especially with MDR1 gene defects), transient injectionsite reactions and environmental impact on dung fauna. Handle with antiparasiticmacrocyclic lactone precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C49H75NO14 |
|---|---|
| Molecular Weight | 900.1 g/mol |
| CAS Number | 123997-26-2 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Eprinex; 75KP30FD8O; N-[(2S,3R,4R,6S)-6-[(2S,3R,4S,6R)-6-[(1'R,2R,3S,4'S,6S,8'R,10'Z,12'S,13'S,14'Z,16'Z,20'R,21'R,24'S)-21',24'-dihydroxy-3,11',13',22'-tetramethyl-2'-oxo-2-propan-2-ylspiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-12'-yl]oxy-4-methoxy-2-methyloxan-3-yl]oxy-4-methoxy-2-methyloxan-3-yl]acetamide; eprinomectinum; Eprizero |
| IUPAC/Chemical Name | N-[(2S,3R,4R,6S)-6-[(2S,3R,4S,6R)-6-[(1'R,2R,3S,4'S,6S,8'R,10'Z,12'S,13'S,14'Z,16'Z,20'R,21'R,24'S)-21',24'-dihydroxy-3,11',13',22'-tetramethyl-2'-oxo-2-propan-2-ylspiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-12'-yl]oxy-4-methoxy-2-methyloxan-3-yl]oxy-4-methoxy-2-methyloxan-3-yl]acetamide |
| InChl Key | WPNHOHPRXXCPRA-TVXIRPTOSA-N |
| InChl Code | InChI=1S/C49H73NO14/c1-25(2)43-28(5)17-18-48(64-43)23-35-20-34(63-48)16-15-27(4)44(26(3)13-12-14-33-24-57-46-42(52)29(6)19-36(47(53)60-35)49(33,46)54)61-40-22-38(56-11)45(31(8)59-40)62-39-21-37(55-10)41(30(7)58-39)50-32(9)51/h12-15,17-19,25-26,28,30-31,34-46,52,54H,16,20-24H2,1-11H3,(H,50,51)/b13-12-,27-15-,33-14-/t26-,28-,30-,31-,34+,35-,36-,37+,38-,39-,40-,41+,42+,43+,44-,45+,46+,48+,49+/m0/s1 |
| References |
3D Conformer.
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