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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of Action
Epalrestat is a selective aldose reductase inhibitor that blocks conversion of glucose to sorbitol in the polyol pathway. This reduces intracellular osmotic stress, oxidative damage and protein glycation—mechanisms central to diabetic neuropathy progression.
Benefits and Advantages
Used in polyol‑pathway studies, diabetic‑neuropathy modelling, oxidative‑stress research, and aldose‑reductase inhibition assays.
Side Effects and Risks
Risks include elevated liver enzymes, nausea, rash and hypersensitivity reactions. Handle with enzyme‑inhibitor precautions.
Datasheet
| Molecular Formula | C15H13NO3S |
|---|---|
| Molecular Weight | 319.4 g/mol |
| CAS Number | 82159-09-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | >47.9 [ug/mL] (The mean of the results at pH 7.4) |
| Purity | Purity information is available upon request (COA). |
| Synonym | epalrestat; 82159-09-9; Kinedak; Epalrestatum; Ono-2235 |
| IUPAC/Chemical Name | 2-[(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid |
| InChl Key | CHNUOJQWGUIOLD-NFZZJPOKSA-N |
| InChl Code | InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8- |
| References |
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