About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Doxazosin mesylate is a selective adrenergic receptor antagonist that induces vasodilation by inhibiting Gqproteincoupled receptor signalling in vascular smooth muscle. This decreases intracellular Ca²⁺ mobilisation and reduces peripheral vascular resistance. It also relaxes smooth muscle in the bladder neck and prostate.
Benefits and Advantages
Used in receptor signalling studies, hypertensionpathway modelling, benignprostatic hyperplasia research, vasculartone assays and adrenergicantagonist SAR work.
Side Effects and Risks
Risks include orthostatic hypotension, dizziness, syncope, edema, tachycardia and fatigue. Handle with adrenergicantagonist precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C23H25N5O5·CH4O3S |
|---|---|
| Molecular Weight | 547.6 g/mol |
| CAS Number | 77883-43-3 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | … Freely soluble in dimethylsulfoxide, soluble in dimethylformamide, slightly soluble in methanol, ethanol, and water (0.8 percent at 25 °C), and very slighlty soluble in acetone and methylene chloride. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Doxazosin mesylate; 77883-43-3; Alfadil; Cardura XL; Doxazosin mesilate |
| IUPAC/Chemical Name | [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone;methanesulfonic acid |
| InChl Key | VJECBOKJABCYMF-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4) |
| References |
3D Conformer.
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