About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Domperidone is a peripherally selective dopamine D₂/D₃ receptor antagonist that enhances gastrointestinal motility and increases lower‑esophageal sphincter tone by blocking dopamine‑mediated inhibition of acetylcholine release. It also raises prolactin levels via pituitary D₂ blockade but minimally crosses the blood–brain barrier.
Benefits and Advantages
Used in GI motility research, D₂‑pathway signalling studies, prokinetic mechanism assays, and endocrine‑prolactin axis investigations.
Side Effects and Risks
Risks include QT prolongation, ventricular arrhythmias, hyperprolactinemia, gynecomastia and GI cramps. Handle with dopamine‑antagonist precautions.
Datasheet
| Molecular Formula | C22H24ClN5O2 |
|---|---|
| Molecular Weight | 425.9 g/mol |
| CAS Number | 57808-66-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | domperidone; 57808-66-9; Motilium; Domperidona; Domperidonum |
| IUPAC/Chemical Name | 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one |
| InChl Key | FGXWKSZFVQUSTL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30) |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
