DILOXANIDE FUROATE

Diloxanide furoate is an antiprotozoal that inhibits Entamoeba histolytica trophozoites. Used for intestinal amoebiasis. Side effects include flatulence, nausea, and rare hypersensitivity. Only GMP materials will be supplied, logistics all according to GDP.

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Product Description


Mechanism of Action

Diloxanide furoate is a luminal amoebicide used against *Entamoeba histolytica*. It dissociates in the gastrointestinal tract into active diloxanide, which interferes with protozoal protein synthesis and cellmembrane function. The furoate ester improves palatability and stability.

Benefits and Advantages

Used in amoebicdisease modelling, luminal antiparasitic assays, protozoal proteinsynthesis research, and esterprodrug pharmacology studies.

Side Effects and Risks

Risks include flatulence, abdominal discomfort, pruritus, and rare hypersensitivity reactions. Handle with antiparasiticcompound precautions.

Only GMP materials will be supplied, logistics all according to GDP.

Datasheet


Molecular Formula

C14H11Cl2NO5

Molecular Weight

328.1 g/mol

CAS Number

3736-81-0

Storage Condition

Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light.

Solubility

>49.2 [ug/mL] (The mean of the results at pH 7.4)

Purity

Purity information is available upon request (COA).

Synonym

DILOXANIDE FUROATE; 3736-81-0; Dichlofurazol; Furentomin; Amebiazol

IUPAC/Chemical Name

[4-[(2,2-dichloroacetyl)-methylamino]phenyl] furan-2-carboxylate

InChl Key

BDYYDXJSHYEDGB-UHFFFAOYSA-N

InChl Code

InChI=1S/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3

References

https://pubchem.ncbi.nlm.nih.gov/compound/19529;

3D Conformer.

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