About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Dihydroartemisinin (DHA) is the active metabolite of all artemisinin derivatives. It generates reactive oxygen species through hemeiron cleavage of its endoperoxide bridge, producing toxic radicals that damage malarial parasite proteins and membranes. It is fastacting with potent antimalarial activity against multiple life stages.
Benefits and Advantages
Used in malariaparasite research, ROSmediated toxicity modelling, endoperoxideactivation assays, drugresistance studies and pharmacodynamic research on Plasmodium species.
Side Effects and Risks
Risks include neurotoxicity at high doses, hematologic suppression, embryofetal risk, GI symptoms and hypersensitivity reactions. Handle with antimalarialcompound precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C15H24O5 |
|---|---|
| Molecular Weight | 284.35 g/mol |
| CAS Number | 71939-50-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Cotexin; Artenimol; Dihydroartemisinine; Salaxin; Santecxin |
| IUPAC/Chemical Name | (1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol |
| InChl Key | BJDCWCLMFKKGEE-ISOSDAIHSA-N |
| InChl Code | InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1 |
| References |
3D Conformer.
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