About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Diflorasone is a high‑potency fluorinated corticosteroid that activates glucocorticoid receptors, suppressing NF‑κB and AP‑1 signalling, reducing inflammatory mediator synthesis, and inhibiting leukocyte infiltration.
Benefits and Advantages
Used in dermatologic inflammation studies, GR‑signalling modelling, topical steroid potency assays, and cytokine‑suppression research.
Side Effects and Risks
Risks include skin atrophy, telangiectasia, hypothalamic‑pituitary suppression, irritation, and systemic absorption effects. Handle as a potent topical glucocorticoid.
Datasheet
| Molecular Formula | C22H29FO5 |
|---|---|
| Molecular Weight | 410.5 g/mol |
| CAS Number | 2557-49-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 8.53e-02 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | diflorasone; 2557-49-5; Diflorasonum; Diflorasona; Murode |
| IUPAC/Chemical Name | (6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |
| InChl Key | WXURHACBFYSXBI-XHIJKXOTSA-N |
| InChl Code | InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1 |
| References |
3D Conformer.
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