About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Difluprednate is an ultrapotent difluorinated corticosteroid with high lipid solubility and strong GR affinity. It suppresses ocular and systemic inflammation by inhibiting phospholipase A, reducing prostaglandin/leukotriene synthesis, and blocking NFBmediated transcription. It is widely used in ocular inflammatory research.
Benefits and Advantages
Used in ophthalmicinflammation modelling, GRactivation studies, cytokinesuppression assays, and corticosteroid potency comparison research.
Side Effects and Risks
Risks include increased intraocular pressure, glaucoma risk, cataract formation, infection susceptibility, and systemic absorption with prolonged exposure. Handle with ophthalmiccorticosteroid precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C27H34F2O7 |
|---|---|
| Molecular Weight | 508.5 g/mol |
| CAS Number | 23674-86-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | difluprednate; 23674-86-4; Durezol; DFBA; Difluprednato |
| IUPAC/Chemical Name | [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate |
| InChl Key | WYQPLTPSGFELIB-JTQPXKBDSA-N |
| InChl Code | InChI=1S/C27H34F2O7/c1-5-6-23(34)36-26(22(33)14-35-15(2)30)10-8-17-18-12-20(28)19-11-16(31)7-9-24(19,3)27(18,29)21(32)13-25(17,26)4/h7,9,11,17-18,20-21,32H,5-6,8,10,12-14H2,1-4H3/t17-,18-,20-,21-,24-,25-,26-,27-/m0/s1 |
| References |
3D Conformer.
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