DEHYDROCORTISONE HEMISUCC
Delavirdine mesylate is a non‑nucleoside reverse transcriptase inhibitor (NNRTI) that binds HIV‑1 reverse transcriptase and blocks viral DNA synthesis. It has been used in combination antiretroviral therapy. Side effects include rash, headache, and gastrointestinal upset, with significant drug–drug interaction potential.
About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Dehydrocortisone hemisuccinate is a water‑soluble ester derivative of dehydrocortisone designed to enhance dissolution and facilitate controlled enzymatic release of the parent corticosteroid. After cleavage of the hemisuccinate ester, the active molecule binds glucocorticoid receptors, suppressing NF‑κB– and AP‑1–driven transcription and modulating metabolic and immune pathways. Its improved solubility allows consistent distribution in aqueous assay systems.
Benefits and Advantages
Used in glucocorticoid‑receptor pathway studies, inflammation‑suppression modelling, soluble‑steroid delivery research, HPA‑axis simulations and steroid‑prodrug activation assays.
Side Effects and Risks
Risks include adrenal suppression, immune impairment, hyperglycemia, fluid retention and possible hepatic stress. Handle with glucocorticoid‑class precautions.
Datasheet
| Molecular Formula | C25H32O7 |
|---|---|
| Molecular Weight | 462.53 g/mol |
| CAS Number | 6051-87-2 |
| Storage Condition | Store in a cool, dry place; protect from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | beta-naphthoflavone; 6051-87-2; 5,6-BENZOFLAVONE; beta-NF; 3-Phenyl-1H-naphtho(2,1-b)pyran-1-one |
| IUPAC/Chemical Name | Cortisone hemisuccinate ester |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
