DALFAMPRIDINE
Dalfampridine is a potassium channel blocker that enhances conduction in demyelinated nerve fibers. It is used to improve walking in patients with multiple sclerosis by increasing nerve signal strength. Benefits include modest gains in walking speed and functional mobility. Side effects include seizures at higher doses, insomnia, dizziness, and urinary tract infections. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Dalfampridine (4aminopyridine) is a voltagegated potassium channel blocker that prolongs actionpotential conduction in demyelinated axons by delaying repolarization. This enhances synaptic transmission and improves neuronal signalling especially in demyelination models.
Benefits and Advantages
Used in multiplesclerosis research, potassiumchannel pharmacology, demyelination modelling, synaptictransmission assays and neuronalexcitability studies.
Side Effects and Risks
Risks include seizures (dosedependent), insomnia, dizziness, paresthesia, UTIs and nausea. Handle as a potent neuroactive channel blocker.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C5H6N2 |
|---|---|
| Molecular Weight | 94.11 g/mol |
| CAS Number | 504-24-5 |
| Storage Condition | Keep container tightly closed in a dry and well-ventilated place. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | 4-aminopyridine; 504-24-5; pyridin-4-amine; 4-Pyridinamine; Fampridine |
| IUPAC/Chemical Name | pyridin-4-amine |
| InChl Key | NUKYPUAOHBNCPY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7) |
| References |
3D Conformer.
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