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Product Description
Mechanism of Action
Clozapine is an atypical antipsychotic with high affinity for D₄ dopaminergic receptors and potent antagonism at 5‑HT₂A receptors. It also modulates histamine, muscarinic and adrenergic receptors. Clozapine reduces mesolimbic dopaminergic signalling while sparing nigrostriatal pathways, giving it strong antipsychotic effects with minimal extrapyramidal symptoms. It additionally enhances NMDA‑glutamatergic function through indirect modulation.
Benefits and Advantages
Used in schizophrenia‑model research, dopaminergic/serotonergic‑pathway analysis, neuroinflammation studies, treatment‑resistant psychosis modelling, and complex receptor‑binding investigations.
Side Effects and Risks
Risks include agranulocytosis, myocarditis, seizures, metabolic syndrome, tachycardia, sedation and hypersalivation. Handle with strict CNS‑active and hematologic‑risk controls.
Datasheet
| Molecular Formula | C18H19ClN4 |
|---|---|
| Molecular Weight | 326.8 g/mol |
| CAS Number | 5786-21-0 |
| Storage Condition | Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | clozapine; 5786-21-0; Leponex; Clozapin; CLOZARIL |
| IUPAC/Chemical Name | 3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine |
| InChl Key | QZUDBNBUXVUHMW-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 |
| References |
3D Conformer.
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