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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Clavulanic acid is a β‑lactamase inhibitor structurally related to penicillins but possessing minimal intrinsic antibacterial activity. It covalently binds serine β‑lactamases, generating inactive acyl‑enzyme intermediates. It restores activity of β‑lactam antibiotics against resistant organisms producing TEM, SHV and certain ESBL-type enzymes.
Benefits and Advantages
Used in inhibitor‑resistance research, β‑lactamase structural studies, combination‑drug PK/PD modelling, synergy evaluation and enzyme‑mechanism profiling of serine‑hydrolase inhibition.
Side Effects and Risks
Risks include GI discomfort, hypersensitivity, hepatic dysfunction and rash. Handle with β‑lactamase‑inhibitor precautions.
Datasheet
| Molecular Formula | C8H9NO5 |
|---|---|
| Molecular Weight | 199.16 g/mol |
| CAS Number | 58001-44-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 3.37e+02 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | CLAVULANIC ACID; 58001-44-8; Acido clavulanico; Acide clavulanique; Clavulansaeure |
| IUPAC/Chemical Name | (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| InChl Key | HZZVJAQRINQKSD-PBFISZAISA-N |
| InChl Code | InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1 |
| References |
3D Conformer.
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