CIPROFIBRATE
Ciprofibrate activates PPAR‑α to reduce triglycerides and improve HDL levels. Side effects include muscle pain, GI upset, and liver enzyme elevation.
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Product Description
Mechanism of Action
Ciprofibrate is a fibrate‑class hypolipidemic agent that activates peroxisome proliferator‑activated receptor‑alpha (PPAR‑α). Activation increases β‑oxidation of fatty acids, enhances lipoprotein‑lipase activity and decreases serum triglycerides while modestly improving HDL levels. It regulates genes controlling lipid metabolism and inflammation.
Benefits and Advantages
Used in PPAR‑α signalling research, lipid‑metabolism studies, triglyceride‑lowering pathway modelling, hepatic fatty‑acid oxidation research and fibrate SAR analysis.
Side Effects and Risks
Risks include hepatotoxicity, myopathy (higher risk with statins), gallstones, GI symptoms and elevated liver enzymes. Handle with lipid‑modulating compound precautions.
Datasheet
| Molecular Formula | C13H14Cl2O3 |
|---|---|
| Molecular Weight | 289.15 g/mol |
| CAS Number | 52214-84-3 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Ciprofibrate; 52214-84-3; 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropanoic acid; Ciprofibratum; Ciprofibrato |
| IUPAC/Chemical Name | 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid |
| InChl Key | KPSRODZRAIWAKH-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17) |
| References |
3D Conformer.
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