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Product Description
Mechanism of Action
Chlorproguanil is a dihydrofolate reductase (DHFR) inhibitor used in antimalarial research. It blocks protozoal DHFR, disrupting folate recycling and inhibiting thymidylate and purine synthesis required for DNA replication. This leads to cytostasis and death of rapidly replicating Plasmodium parasites.
Benefits and Advantages
Used in malaria-drug resistance studies, folate-cycle modelling, DHFR-mutation assays, combination-antimalarial research (e.g., with dapsone), and structure–activity investigations of antifolate compounds.
Side Effects and Risks
Risks include hepatotoxicity, GI disturbances, bone-marrow suppression, folate deficiency and hypersensitivity. Handle with antifolate safety protocols.
Datasheet
| Molecular Formula | C11H16ClN5 |
|---|---|
| Molecular Weight | 288.17 g/mol |
| CAS Number | 537-21-3 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Chlorproguanil; 1-(3,4-Dichlorophenyl)-5-isopropylbiguanide; Clorproguanil; Clorpreguanile; Chlorproguanilum |
| IUPAC/Chemical Name | (1E)-1-[amino-(3,4-dichloroanilino)methylidene]-2-propan-2-ylguanidine |
| InChl Key | ISZNZKHCRKXXAU-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C11H15Cl2N5/c1-6(2)16-10(14)18-11(15)17-7-3-4-8(12)9(13)5-7/h3-6H,1-2H3,(H5,14,15,16,17,18) |
| References |
3D Conformer.
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