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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of Action
Chlorphenamine (chlorpheniramine) maleate is a first-generation H₁-antihistamine that competitively antagonises histamine at H₁ receptors. It reduces capillary permeability, vasodilation, pruritus and allergic inflammatory responses. Owing to its strong CNS penetration, it exhibits sedative, anticholinergic and antiemetic effects. It also shows weak serotonin-reuptake inhibition.
Benefits and Advantages
Used in allergy-modelling studies, histamine-receptor signalling research, antihistamine SAR evaluations, central-sedation pathway analysis, and behavioural pharmacology research. Frequently utilised as a reference sedating antihistamine.
Side Effects and Risks
Risks include sedation, cognitive impairment, anticholinergic effects (dry mouth, urinary retention, constipation), tachycardia, dizziness and paradoxical excitation in children. Handle as a CNS-active antihistamine.
Datasheet
| Molecular Formula | C20H23ClN2O4 |
|---|---|
| Molecular Weight | 390.86 g/mol |
| CAS Number | 113-92-8 |
| Storage Condition | Store in a cool, dry place; protected from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | chlorpheniramine; Chlorphenamine; 132-22-9; Chlorophenylpyridamine; Haynon |
| IUPAC/Chemical Name | (3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine maleate |
| InChl Key | KMTPZPUYURWXNF-FNORWQNLSA-N |
| InChl Code | InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3 |
| References | PubChem; ChemBL; FDA substance registry; |
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