About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Certolizumab pegol is a PEGylated Fab’ fragment that neutralises tumour necrosis factoralpha (TNF). It lacks an Fc region, preventing complement activation or antibodydependent cellular cytotoxicity. By binding soluble and membranebound TNF, it inhibits downstream NF-κB activation, cytokine release, endothelial adhesionmolecule expression and inflammatorycell recruitment.
Benefits and Advantages
Used in TNF signalling research, autoimmunedisease modelling (RA, Crohns), cytokinenetwork studies, PEGbioconjugation research, and Fabfragment pharmacokinetic optimisation. Valuable for understanding selective TNF neutralisation without Fcmediated effects.
Side Effects and Risks
Risks include immunosuppression, infection risk (TB reactivation), injectionsite reactions, malignancy risk (longterm), and immunedysregulation. Handle as a biologically active monoclonalfragment therapeutic.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C6464H9988N1722O2026S42 |
|---|---|
| Molecular Weight | 90000.0 g/mol |
| CAS Number | 428863-50-7 |
| Storage Condition | Store in a cool, dry place; protected from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | Xaliproden; 135354-02-8; xaliprodene; xaliprodeno; V8QL94KNQO |
| IUPAC/Chemical Name | Monoclonal antibody Fabâ fragment conjugated to polyethylene glycol |
| InChl Key | Unavailable for large molecules |
| InChl Code | Unavailable for large molecules |
| References | PubChem; ChemBL; FDA substance registry; |
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