About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Certolizumab pegol is a PEGylated Fab’ fragment that neutralises tumour necrosis factor‑alpha (TNF‑α). It lacks an Fc region, preventing complement activation or antibody‑dependent cellular cytotoxicity. By binding soluble and membrane‑bound TNF‑α, it inhibits downstream NF‑κB activation, cytokine release, endothelial adhesion‑molecule expression and inflammatory‑cell recruitment.
Benefits and Advantages
Used in TNF‑α signalling research, autoimmune‑disease modelling (RA, Crohn’s), cytokine‑network studies, PEG‑bioconjugation research, and Fab‑fragment pharmacokinetic optimisation. Valuable for understanding selective TNF neutralisation without Fc‑mediated effects.
Side Effects and Risks
Risks include immunosuppression, infection risk (TB reactivation), injection‑site reactions, malignancy risk (long‑term), and immune‑dysregulation. Handle as a biologically active monoclonal‑fragment therapeutic.
Datasheet
| Molecular Formula | C6464H9988N1722O2026S42 |
|---|---|
| Molecular Weight | 90000.0 g/mol |
| CAS Number | 428863-50-7 |
| Storage Condition | Store in a cool, dry place; protected from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | Xaliproden; 135354-02-8; xaliprodene; xaliprodeno; V8QL94KNQO |
| IUPAC/Chemical Name | Monoclonal antibody Fabâ fragment conjugated to polyethylene glycol |
| InChl Key | Unavailable for large molecules |
| InChl Code | Unavailable for large molecules |
| References | PubChem; ChemBL; FDA substance registry; |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
