About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Ceftriaxone is a thirdgeneration cephalosporin with long halflife and broad activity against gramnegative and grampositive pathogens. It binds PBPs and disrupts cellwall synthesis. Its strong CNS penetration makes it a primary agent in meningitis models. High protein binding contributes to sustained serum levels.
Benefits and Advantages
Used extensively in CNSinfection modelling, sepsis research, PBPselectivity studies, lactam PK/PD evaluations, neonatal infection models and resistancemechanism investigations. A global reference drug for extendedspectrum cephalosporins.
Side Effects and Risks
Risks include biliary sludge, hypersensitivity, rare haemolysis, GI upset and selection of resistant strains. Handle with strict antimicrobial precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C18H18N8O7S3 |
|---|---|
| Molecular Weight | 554.6 g/mol |
| CAS Number | 73384-59-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 1.05e-01 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | ceftriaxone; 73384-59-5; Rocephin; Biotrakson; Ceftriaxona |
| IUPAC/Chemical Name | (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| InChl Key | VAAUVRVFOQPIGI-SPQHTLEESA-N |
| InChl Code | InChI=1S/C18H18N8O7S3/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32)/b24-8-/t9-,15-/m1/s1 |
| References |
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