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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of action
Carbimazole is a thionamide prodrug converted in vivo to the active metabolite methimazole. It inhibits thyroid peroxidase (TPO), the enzyme responsible for iodination of tyrosine residues on thyroglobulin and coupling reactions that form T₃ and T₄. This blocks synthesis of thyroid hormones without affecting their release, leading to gradual reduction of circulating thyroid levels.
Benefits and advantages
Used in thyroid-pathophysiology research, Graves’ disease modelling, TPO-enzyme studies, autoimmune-thyroid disease investigations and comparative antithyroid SAR profiling. It is a central tool in understanding hormone-synthesis control and feedback regulation within the hypothalamic–pituitary–thyroid axis.
Side effects and risks
Risks include agranulocytosis, hepatotoxicity, rash, arthralgia and gastrointestinal upset. Careful handling and monitoring are required due to its potential for serious idiosyncratic reactions.
Datasheet
| Molecular Formula | C7H10N2O2S |
|---|---|
| Molecular Weight | 186.23 g/mol |
| CAS Number | 2192-20-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 3.14e+00 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | Carbimazole; 22232-54-8; Athyromazole; Carbimazol; Carbethoxymethimazole |
| IUPAC/Chemical Name | ethyl 3-methyl-2-sulfanylideneimidazole-1-carboxylate |
| InChl Key | CFOYWRHIYXMDOT-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3 |
| References |
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