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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Captopril is an angiotensin‑converting enzyme (ACE) inhibitor that prevents conversion of angiotensin I to angiotensin II. This reduces vasoconstriction, aldosterone release, sympathetic outflow and sodium retention. It also inhibits bradykinin degradation, enhancing vasodilation via nitric oxide and prostaglandin pathways. Its sulfhydryl group contributes to potent ACE inhibition.
Benefits and advantages
Used in cardiovascular research, RAAS‑pathway modelling, hypertension studies, heart‑failure investigations, endothelial‑function experiments and ACE‑inhibitor SAR analysis. Also used to examine renoprotective mechanisms in diabetic nephropathy.
Side effects and risks
Risks include cough, hypotension, hyperkalaemia, angioedema, renal impairment and rash. Handle with antihypertensive‑active compound precautions.
Datasheet
| Molecular Formula | C9H15NO3S |
|---|---|
| Molecular Weight | 217.29 g/mol |
| CAS Number | 5747-74-2 |
| Storage Condition | Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. |
| Solubility | Freely soluble |
| Purity | Purity information is available upon request (COA). |
| Synonym | captopril; 62571-86-2; Capoten; L-Captopril; Captopryl |
| IUPAC/Chemical Name | (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid |
| InChl Key | FAKRSMQSSFJEIM-RQJHMYQMSA-N |
| InChl Code | InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1 |
| References |
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