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Product Description
Mechanism of action
Canrenone is an active metabolite of spironolactone and a mineralocorticoid receptor antagonist. It inhibits aldosterone-mediated transcription of sodium-channel proteins in the distal nephron, reducing sodium retention and potassium loss. It also exhibits antifibrotic and mild antiandrogenic effects.
Benefits and advantages
Used in renal-electrolyte research, aldosterone-pathway investigations, heart-failure studies, RAAS-modelling, anti-fibrotic mechanism studies and endocrine-modulation research.
Side effects and risks
Risks include hyperkalaemia, endocrine effects (e.g., gynecomastia), hypotension and renal impairment. Handle as a steroidal mineralocorticoid antagonist.
Datasheet
| Molecular Formula | C22H28O3 |
|---|---|
| Molecular Weight | 340.5 g/mol |
| CAS Number | 976-71-6 |
| Storage Condition | Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. |
| Solubility | greater than or equal to 100 mg/mL at 70 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | CANRENONE; 976-71-6; Aldadiene; SC-9376; Canrenonum |
| IUPAC/Chemical Name | (8R,9S,10R,13S,14S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione |
| InChl Key | UJVLDDZCTMKXJK-WNHSNXHDSA-N |
| InChl Code | InChI=1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1 |
| References |
3D Conformer.
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