BUCILLAMINE

Bucillamine is a thiol antioxidant and DMARD used in rheumatoid arthritis. Benefits include reduced inflammation. Side effects include rash, hepatotoxicity, and proteinuria. Only GMP materials will be supplied, logistics all according to GDP.

SKU: 848942a9fe23 Category: Tag:

Product Description


Mechanism of action

Bucillamine is a thiolcontaining cysteine derivative with strong antioxidant and immunomodulatory properties. It donates thiol groups, enhances glutathione recycling, scavenges reactive oxygen species and modulates inflammatory signalling pathways. It also acts as a diseasemodifying antirheumatic agent (DMARD).

Benefits and advantages

Used in oxidativestress studies, glutathionemetabolism research, redoxbiology modelling, autoimmunedisease investigations, rheumatology drugdevelopment and thiolreactivity assays.

Side effects and risks

Risks include rash, proteinuria, agranulocytosis, hepatic enzyme changes and hypersensitivity reactions. Handle under thiolreactivecompound safety controls.

Only GMP materials will be supplied, logistics all according to GDP.

Datasheet


Molecular Formula

C7H13NO3S2

Molecular Weight

223.3 g/mol

CAS Number

65002-17-7

Storage Condition

Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light.

Solubility

Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance.

Purity

Purity information is available upon request (COA).

Synonym

bucillamine; 65002-17-7; Tiobutarit; Bucilamina; Bucilant

IUPAC/Chemical Name

(2R)-2-[(2-methyl-2-sulfanylpropanoyl)amino]-3-sulfanylpropanoic acid

InChl Key

VUAFHZCUKUDDBC-BYPYZUCNSA-N

InChl Code

InChI=1S/C7H13NO3S2/c1-7(2,13)6(11)8-4(3-12)5(9)10/h4,12-13H,3H2,1-2H3,(H,8,11)(H,9,10)/t4-/m0/s1

References

https://pubchem.ncbi.nlm.nih.gov/compound/656604;

3D Conformer.

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