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Product Description
Mechanism of action
Brucine is an alkaloid structurally related to strychnine, acting as a competitive antagonist at inhibitory glycine receptors in the spinal cord. This leads to heightened neuronal excitability and increased reflex activity. It also exhibits mild analgesic, anti-inflammatory and plantderived neuroactive properties.
Benefits and advantages
Used in neuropharmacology, glycinereceptor studies, spinalreflex modelling, alkaloid SAR research and behaviouraltoxicology investigations. Its structural similarity to strychnine makes it valuable for ligandreceptor comparison studies.
Side effects and risks
Highly toxic; risks include convulsions, respiratory arrest, severe CNS excitation, muscle rigidity and neurotoxicity. Handle with maximumlevel alkaloid safety protocols.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C23H26N2O4 |
|---|---|
| Molecular Weight | 394.5 g/mol |
| CAS Number | 357-57-3 |
| Storage Condition | Storage temperature: Ambient |
| Solubility | Crystals. Sol in water or alcohol. The solns are neutral or slightly acid. /Hydrochloride/ |
| Purity | Purity information is available upon request (COA). |
| Synonym | BRUCINE; 357-57-3; 10,11-Dimethoxystrychnine; Brucinum; (-)-Brucine |
| IUPAC/Chemical Name | (4aR,5aS,8aR,13aS,15aS,15bR)-10,11-dimethoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one |
| InChl Key | RRKTZKIUPZVBMF-IBTVXLQLSA-N |
| InChl Code | InChI=1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+/m0/s1 |
| References |
3D Conformer.
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