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Product Description
Mechanism of action
Bretylium is an adrenergic neuronal‑blocking agent that initially releases norepinephrine from presynaptic terminals, followed by long‑lasting inhibition of catecholamine release. In cardiac tissue it prolongs action potential duration by blocking potassium channels, giving it class III antiarrhythmic properties.
Benefits and advantages
Used in electrophysiology research, arrhythmia models, sympathetic‑nerve function studies, potassium‑channel analysis and investigation of neuronal‑blocking mechanisms.
Side effects and risks
Risks include profound hypotension, dizziness, arrhythmias, GI upset and sympathetic blockade. Handle with cardiovascular‑active compound precautions.
Datasheet
| Molecular Formula | C18H24BrNO3S |
|---|---|
| Molecular Weight | 414.4 g/mol |
| CAS Number | 61-75-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | >62.2 [ug/mL] (The mean of the results at pH 7.4) |
| Purity | Purity information is available upon request (COA). |
| Synonym | Bretylium tosylate; 61-75-6; Bretylol; Bretylium tosilate; Darentin |
| IUPAC/Chemical Name | (2-bromophenyl)methyl-ethyl-dimethylazanium;4-methylbenzenesulfonate |
| InChl Key | KVWNWTZZBKCOPM-UHFFFAOYSA-M |
| InChl Code | InChI=1S/C11H17BrN.C7H8O3S/c1-4-13(2,3)9-10-7-5-6-8-11(10)12;1-6-2-4-7(5-3-6)11(8,9)10/h5-8H,4,9H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1 |
| References |
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