BRETYLIUM TOSYLATE
Bretylium tosylate is an antiarrhythmic agent that blocks norepinephrine release and prolongs cardiac action potential. It is reserved for lifethreatening ventricular arrhythmias. Side effects include hypotension, nausea, and dizziness. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Bretylium is an adrenergic neuronalblocking agent that initially releases norepinephrine from presynaptic terminals, followed by longlasting inhibition of catecholamine release. In cardiac tissue it prolongs action potential duration by blocking potassium channels, giving it class III antiarrhythmic properties.
Benefits and advantages
Used in electrophysiology research, arrhythmia models, sympatheticnerve function studies, potassiumchannel analysis and investigation of neuronalblocking mechanisms.
Side effects and risks
Risks include profound hypotension, dizziness, arrhythmias, GI upset and sympathetic blockade. Handle with cardiovascularactive compound precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C18H24BrNO3S |
|---|---|
| Molecular Weight | 414.4 g/mol |
| CAS Number | 61-75-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | >62.2 [ug/mL] (The mean of the results at pH 7.4) |
| Purity | Purity information is available upon request (COA). |
| Synonym | Bretylium tosylate; 61-75-6; Bretylol; Bretylium tosilate; Darentin |
| IUPAC/Chemical Name | (2-bromophenyl)methyl-ethyl-dimethylazanium;4-methylbenzenesulfonate |
| InChl Key | KVWNWTZZBKCOPM-UHFFFAOYSA-M |
| InChl Code | InChI=1S/C11H17BrN.C7H8O3S/c1-4-13(2,3)9-10-7-5-6-8-11(10)12;1-6-2-4-7(5-3-6)11(8,9)10/h5-8H,4,9H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1 |
| References |
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