ATROVASTATIN
Avapritinib is a tyrosine kinase inhibitor targeting mutant KIT and PDGFRA, used for advanced GIST. Benefits include strong activity against resistant tumors. Side effects include edema, cognitive effects, nausea, fatigue, and anemia, requiring dosage monitoring. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Atrovastatin appears to refer to a statin-analogue compound closely related to atorvastatin, sharing the core mechanism of competitive inhibition of HMG-CoA reductase. By reducing hepatic cholesterol synthesis, it promotes upregulation of LDL receptors and enhances clearance of circulating LDL, thus modulating plasma lipid profiles.
Benefits and advantages
Such analogues are commonly used in medicinal chemistry and comparative pharmacology to explore structureactivity relationships within the statin class, including differences in potency, lipophilicity, tissue selectivity and drugdrug interaction potential.
Side effects and risks
Risks are expected to resemble those of other statins, including myotoxicity, hepatic enzyme elevations and interaction with other hepatically cleared drugs. As an experimental statin analogue, it must be handled in accordance with potent enzyme inhibitor safety standards.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C33H35FN2O5 |
|---|---|
| Molecular Weight | 558.6 g/mol |
| CAS Number | 134523-00-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | RefChem:715469; GlyTouCan:G43288VA; G43288VA; Atorvastatin(Relative); 842103-12-2 |
| IUPAC/Chemical Name | (S)-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid |
| InChl Key | MOTSYZDLTMFJMB-KAYWLYFJSA-N |
| InChl Code | InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40) |
| References |
3D Conformer.
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