ANTIPYRINE
Apamin is a neurotoxic peptide from bee venom that selectively blocks smallconductance calciumactivated potassium channels. It is studied in neuroscience for its modulatory effects. Risks include neurotoxicity, allergic reactions, and systemic symptoms following exposure. Only GMP materials will be supplied, logistics all according to GDP.
About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Antipyrine is a classical pyrazolone analgesic and antipyretic that exerts its effect by reversible inhibition of prostaglandin synthesis via central COX suppression. It displays excellent oral absorption and penetrates biological membranes efficiently. Antipyrine is particularly notable for its predictable hepatic metabolism, making it a goldstandard probe substrate for cytochrome P450mediated clearance.
Benefits and advantages
Widely used in hepatic enzyme profiling, pharmacokinetic modelling, drugdrug interaction studies, and assessment of hepatic metabolic capacity. Its reliable clearance profile makes it a benchmark compound in microsomal metabolic activity tests.
Side effects and risks
Overexposure may cause dizziness, rash, blood dyscrasias, or hepatotoxicity. Due to its metabolic liability, strict laboratory handling is required.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C11H12N2O |
|---|---|
| Molecular Weight | 188.23 g/mol |
| CAS Number | 60-80-0 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | antipyrine; Phenazone; 60-80-0; Antipyrin; Analgesine |
| IUPAC/Chemical Name | 1,5-dimethyl-2-phenylpyrazol-3-one |
| InChl Key | VEQOALNAAJBPNY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3 |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
