ANCITABINE
Ancitabine is a cytidine analogue with antimetabolic anticancer activity, interfering with DNA synthesis. Benefits include inhibition of rapidly proliferating tumor cells. Side effects may include bone marrow suppression, gastrointestinal upset, and fatigue. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Ancitabine (1Darabinofuranosylcytosine phosphate derivative) is a nucleoside analog that functions as a prodrug of cytarabine. After intracellular phosphorylation, ancitabine is converted into araCTP, which inhibits DNA polymerase and is incorporated into DNA, causing chain termination. This mechanism disrupts DNA synthesis in rapidly dividing cells.
Benefits and advantages
Ancitabine is important for studies on leukemia cell kinetics, nucleoside metabolism, and prodrug activation pathways. Its sustainedrelease pharmacology allows modeling longterm cytotoxic exposure and intracellular phosphorylation dynamics.
Side effects and risks
Cytotoxicity, myelosuppression, nausea, hepatic stress, and mucositis are expected risks. Only certified cytotoxicgrade handling is permitted.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C9H11N3O4 |
|---|---|
| Molecular Weight | 225.20 g/mol |
| CAS Number | 31698-14-3 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | H2O 200 ( mg/mL) |
| Purity | Purity information is available upon request (COA). |
| Synonym | ANCITABINE; Cyclocytidine; 31698-14-3; 2,2'-Cyclocytidine; Ancitabina |
| IUPAC/Chemical Name | (2R,4R,5R,6S)-4-(hydroxymethyl)-10-imino-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-5-ol |
| InChl Key | BBDAGFIXKZCXAH-CCXZUQQUSA-N |
| InChl Code | InChI=1S/C9H11N3O4/c10-5-1-2-12-8-7(16-9(12)11-5)6(14)4(3-13)15-8/h1-2,4,6-8,10,13-14H,3H2/t4-,6-,7+,8-/m1/s1 |
| References |
3D Conformer.
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