AMYKACIN
Amykacin (amikacin variant) is an aminoglycoside antibiotic that inhibits bacterial protein synthesis, effective against severe gramnegative infections. Benefits include activity against resistant strains. Side effects include nephrotoxicity, ototoxicity, and neuromuscular blockade, requiring drug-level monitoring and renal dose adjustment. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Amykacin (likely variant of amikacin or aminoglycoside derivative) exerts bactericidal effects by binding the 30S ribosomal subunit, inhibiting accurate tRNA positioning and causing mistranslation and halted protein synthesis.
Benefits and advantages
Useful in comparative aminoglycoside studies, ribosomal binding kinetics research and antimicrobial resistance profiling.
Side effects and risks
Nephrotoxicity, ototoxicity, neuromuscular blockade. Strict antimicrobial handling required.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C22H43N5O13 |
|---|---|
| Molecular Weight | 585.61 g/mol |
| CAS Number | 37517-28-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | DTXSID60860546; 4-amino-n-{5-amino-2-[(3-amino-3-deoxyhexopyranosyl)oxy]-4-[(6-amino-6-deoxyhexopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide; 4-Amino-N-(5-amino-2-((3-amino-3-deoxyhexopyranosyl)oxy)-4-((6-amino-6-deoxyhexopyranosyl)oxy)-3-hydroxycyclohexyl)-2-hydroxybutanamide; RefChem:1070310; DTXCID10209183 |
| IUPAC/Chemical Name | 4-amino-N-[5-amino-2-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide |
| InChl Key | LKCWBDHBTVXHDL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C22H43N5O13/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36) |
| References |
3D Conformer.
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