About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Aminoglutethimide is an inhibitor of adrenal steroidogenesis and aromatase. It blocks the cholesterol side- chain cleavage enzyme (CYP11A1), reducing the synthesis of glucocorticoids, mineralocorticoids and sex steroids in the adrenal cortex, and also inhibits aromatase (CYP19), thereby decreasing the peripheral conversion of androgens to oestrogens.
Benefits and advantages
Aminoglutethimide has been used as an adrenolytic agent in the treatment of hormone-dependent breast cancer and Cushing’s syndrome, often in combination with glucocorticoid replacement to control excess adrenal hormone production. It is also of continuing interest as a research tool in endocrinology for dissecting steroid biosynthetic pathways.
Side effects and risks
Adverse effects include sedation, dizziness, skin rash, gastrointestinal disturbances, ataxia, hypothyroidism and, with prolonged use, adrenal insufficiency. Because it profoundly alters steroid hormone synthesis, treatment requires specialist supervision, hormone monitoring and appropriate replacement strategies. The raw material must be handled with great care to avoid occupational exposure, and manufacturing must follow stringent controls for potent endocrine-active substances.
Professional use only. Supplied exclusively to licensed manufacturers and healthcare or research institutions.
Datasheet
| Molecular Formula | C13H16N2O2 |
|---|---|
| Molecular Weight | 232.28 g/mol |
| CAS Number | 125-84-8 |
| Storage Condition | Protect from light. Do not store above 30 °F (86 °C). Dispense in tight, light resistant container. |
| Solubility | Practically insoluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | aminoglutethimide; 125-84-8; dl-Aminoglutethimide; Cytadren; Orimeten |
| IUPAC/Chemical Name | 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione |
| InChl Key | ROBVIMPUHSLWNV-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17) |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
