AMIFOSTINE
AMIFOSTINE is being supplied by MedicaPharma in pharma GMP grade. We have several principals on hand for this material. Just send us your quote request and we will serve you. Amifostine(ethiofos) is a cytoprotective adjuvant used in cancer chemotherapyandradiotherapyinvolvingDNA-binding chemotherapeutic agents. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Indications
Amifostine is used therapeutically to reduce the incidence ofneutropenia-related fever and infection induced by DNA-binding chemotherapeutic agents includingalkylating agents(e.g.cyclophosphamide) and platinum-containing agents (e.g.cisplatin). It is also used to decrease the cumulativenephrotoxicity associated with platinum-containing agents. It is also indicated to reduce the incidence of xerostomia in patients undergoing radiotherapy for head and neck cancer. Amifostine was originally indicated to reduce the cumulative renal toxicity from cisplatin in non-small cell lung cancer. However, while nephroprotection was observed, the probability that amifostine could protect tumors could not be excluded. Additional data have shown that similar-mediated tumor protection, in any clinical scenario, is unlikely.
Mechanism of action
Inside cells, the material detoxifies reactive metabolites of platinum and alkylating agents, as well as scavenges free radicals. Other possible effects include acceleratedDNA repair, induction of cellular hypoxia, inhibition of apoptosis, alteration of gene expression and modification of enzyme activity. Itis believed to radioprotect normal tissue via Warburg-type effects.
Pharmacokinetics
WR-1065, 2-((aminopropyl)amino)ethanethiol, theactive metabolite of the concerning material.
Amifostine is an organic thiophosphateprodrugwhich is hydrolysedin vivobyalkaline phosphataseto the active cytoprotectivethiolmetabolite, WR-1065. The selective protection of non-malignant tissues is believed to be due to higher alkaline phosphatase activity, higherpH, and vascular permeation of normal tissues. It can be administered intravenously or subcutaneously after reconstitution with normal saline. Infusions lasting less than 15 minutes decrease the risk of adverse effects. The patient should be well-hydrated prior to administration.
Adverse effects
Commonside effects of the material include hypocalcemia,diarrhea,nausea,vomiting, sneezing, somnolence, andhiccoughs. Serious side effects include: hypotension (found in 62% of patients),erythema multiforme,StevensJohnson syndromeandtoxic epidermal necrolysis, immunehypersensitivitysyndrome,erythroderma,anaphylaxis, and loss of consciousness (rare).
Contraindications
Contraindications to receiving this material include hypersensitivityto amifostine andaminothiolcompounds like WR-1065. Ethyol containsmannitol. (Source: Wikipedia) Only GMP materials will be supplied, logistics all according to GDP.
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