ACETOHYDROXAMIC ACID
Acetohydroxamic acid is a urease inhibitor used to manage chronic UTIs caused by urease-producing bacteria and prevent struvite stones. Benefits include reduced ammonia formation and improved infection control. Side effects include headache, nausea, thrombophlebitis, and rare hematologic abnormalities. Only GMP materials will be supplied, logistics all according to GDP.
About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Acetohydroxamic acid is a potent reversible inhibitor of the bacterial enzyme urease. By blocking urease, it reduces the hydrolysis of urea to ammonia in the urinary tract, thereby lowering urinary ammonia concentration and increasing the solubility of phosphate. This helps prevent growth and recurrence of infectionrelated struvite and calcium phosphate kidney stones.
Benefits and advantages
When used alongside appropriate antimicrobial therapy, acetohydroxamic acid can significantly reduce stone burden and recurrence in patients with chronic ureaseproducing urinary tract infections. It is particularly valuable in complex cases where surgical or mechanical approaches alone are insufficient.
Side effects and risks
Adverse effects include gastrointestinal disturbances, headache, rash, anaemia and, less commonly, thrombophlebitis and neurological symptoms. Because of teratogenicity observed in animal studies, its use is contraindicated in pregnancy. Longterm therapy requires regular monitoring of blood counts and renal function. Handling of the raw material should follow strict occupational safety guidelines.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C2H5NO2 |
|---|---|
| Molecular Weight | 75.07 g/mol |
| CAS Number | 546-88-3 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | acetohydroxamic acid; N-Hydroxyacetamide; 546-88-3; Acetylhydroxamic acid; Lithostat |
| IUPAC/Chemical Name | N-hydroxyacetamide |
| InChl Key | RRUDCFGSUDOHDG-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4) |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
