RAPAMYCIN (SIROLIMUS)
Rapamycin (Sirolimus) is a research-grade compound used in advanced pharmaceutical and biochemical studies. Chemical & Pharmacological Characteristics Experimental behavior is governed by solubility, stability, ionization state, and matrix interactions. Proper formulation control is essential. Mechanism of Action No single receptor-driven mechanism is assumed; observed effects are concentration- and context-dependent. It is primarily applied to investigate compound-specific mechanisms, physicochemical behavior, and analytical or formulation-relevant characteristics under controlled laboratory conditions. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Chemical & Pharmacological Characteristics
Experimental behavior is governed by solubility, stability, ionization state, and matrix interactions. Proper formulation control is essential.
Mechanism of Action
No single receptor-driven mechanism is assumed; observed effects are concentration- and context-dependent.
Interpretation should include matched controls to separate direct chemical effects from secondary stress responses.
Advanced
- Analytical reference and quality control
- Formulation development and stability screening
- Compatibility testing with excipients and packaging
- Comparative toxicology benchmarking
- Documentation support for R&D workflows
Toxicodynamics & Cellular Hazard Spectrum
- Nonspecific cytotoxicity at high exposure
- Solubility or aggregation artifacts
- Matrix-dependent assay interference
- Handling-related irritation risk
- Dispose according to laboratory waste regulations
For expert laboratory research only – not intended for biological or therapeutic exposure.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C51H79NO13 |
|---|---|
| Molecular Weight | 914.2 g/mol |
| CAS Number | 53123-88-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Sol in ether, chloroform, acetone, methanol, and DMF; very sparingly sol in hexane and petr ether. |
| Purity | Purity information is available upon request (COA). |
| Synonym | rapamycin; Sirolimus; (-)-Rapamycin; 53123-88-9; Rapamune |
| IUPAC/Chemical Name | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone |
| InChl Key | QFJCIRLUMZQUOT-HPLJOQBZSA-N |
| InChl Code | InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1 |
| References | https://pubchem.ncbi.nlm.nih.gov/compound/5284616; small-molecule |
3D Conformer.
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