HEMIN
Hemin is an iron-containing porphyrin used to treat acute porphyria by inhibiting ALA synthase. Benefits include reduced neurotoxic metabolite production. Side effects include phlebitis, headache, and iron overload risks.
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Product Description
Mechanism of Action
This compound (ID 26325) exhibits a multifaceted biochemical activity profile involving receptor-level modulation, enzyme-pathway interference, and intracellular signalling adjustments. It can alter phosphorylation dynamics, metabolic flux balance, mitochondrial function, and the regulation of adaptive stress-response pathways.
Benefits and Advantages
Suitable for mechanistic pathway research, multi‑omics profiling, receptor-binding investigations, metabolic modelling, and experimental systems requiring controlled biochemical perturbation. Its predictable interaction patterns make it reliable for pharmacodynamic benchmarking and preclinical assay calibration.
Side Effects and Risks
Potential risks include oxidative stress imbalance, cytoskeletal disruption, unintended receptor crosstalk, dose‑dependent cytotoxicity, and overstimulation or suppression of regulatory pathways. Laboratory use only with appropriate biosafety precautions.
Datasheet
| Molecular Formula | C34H32ClFeN4O4 |
|---|---|
| Molecular Weight | 651.9 g/mol |
| CAS Number | 16009-13-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | RefChem:1093269; Npc76529; hemin; Chlorohemin; Panhematin |
| IUPAC/Chemical Name | 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(3+);chloride |
| InChl Key | BTIJJDXEELBZFS-UHFFFAOYSA-K |
| InChl Code | InChI=1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3 |
| References |
3D Conformer.
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