4-Dimethylaminopyridine
4Dimethylaminopyridine (DMAP) is an acylation catalyst used in organic synthesis. Not for therapeutic use. Exposure risks include skin and respiratory irritation, headache, and potential systemic toxicity with significant contact. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
4-Dimethylaminopyridine displays a highdimensional biochemical interaction profile, integrating catalyticdomain modulation, multiaxis signalling interference, mitochondrialnetwork recalibration, ionflux redistribution, membranepotential rebalancing, cytoskeletal remodelling, redoxequilibrium restructuring and transcriptionfactor pathway reprogramming. Its molecular topology supports interaction with catalytic residues, allosteric microdomains, transmembrane helices, nucleotidebinding pockets, redoxbuffer centres and polymeric scaffolding complexes, enabling wideband influence across metabolic, genomic, structural and electrophysiological layers.
At the signalling level, 4-Dimethylaminopyridine may reconfigure phosphorylation landscapes spanning ERK/MAPK/JNK/p38 and PI3KAKT axes, modulate Gprotein coupling states, reorganise Ca²⁺ microdomain geometry, adjust IP/DAG cascade topology, and recalibrate cAMPPKA amplitude distributions. Mitochondrial effects can include ETCcomplex rebalancing, ATP/ADP flux modulation, ROSthreshold displacement, membranepotential polarity shifts and bidirectional stresssignal integration between ER and mitochondrial compartments.
Advanced
- Kinomescale catalyticcascade interference mapping
- Highresolution docking & conformationaltransition simulations
- UPR/ERstress, mitophagy & autophagicflux network analysis
- Full multiomics integration (RNAseq, proteomics, phosphoproteomics, metabolomics)
- Cytoskeletal mechanics & polymerturnover/forcedistribution modelling
- Cellfate pathway simulations (apoptosis, necroptosis, ferroptosis, parthanatos)
- AIdriven SAR/QSAR pipelines for compoundperformance prediction
Toxicodynamics & Hazard Spectrum
- Rapid ROS escalation & antioxidantbuffer saturation
- Mitochondrial fragmentation or ETCaxis suppression
- Severe Na⁺/K⁺/Ca²⁺ ionic-flux destabilisation
- Cytoskeletal depolymerisation & membrane-integrity loss
- Hyperactivation of NF-κB, STAT & IRF inflammatory regulators
- Induction of multiaxis programmed-cell-death pathways
- Epigenetic drift including methylation/acetylation imbalance
For expert laboratory research only not intended for biological or therapeutic exposure.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C7H10N2 |
|---|---|
| Molecular Weight | 122.17 g/mol |
| CAS Number | 1122-58-3 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | 4-Dimethylaminopyridine; 1122-58-3; N,N-Dimethylpyridin-4-amine; dmap; 4-(Dimethylamino)pyridine |
| IUPAC/Chemical Name | N,N-dimethylpyridin-4-amine |
| InChl Key | VHYFNPMBLIVWCW-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C7H10N2/c1-9(2)7-3-5-8-6-4-7/h3-6H,1-2H3 |
| References |
3D Conformer.
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