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Product Description
Mechanism of Action
VORINOSTAT (ID 27832) exhibits a high‑dimensional biochemical interaction matrix spanning signalling‑axis disruption, catalytic‑domain modulation, mitochondrial‑network recalibration, ion‑flux redistribution, cytoskeletal‑architecture remodelling, membrane‑potential rebalancing and transcription‑factor pathway restructuring. Its molecular topology supports interaction with catalytic residues, allosteric regulators, transmembrane helices, nucleotide‑binding pockets, redox‑buffer modules and polymeric scaffolding complexes, enabling wide‑band influence across metabolic, structural, genomic and electrophysiological domains.
Mechanistically, VORINOSTAT may reshape phosphorylation maps across ERK/MAPK/JNK/p38 axes, alter PI3K–AKT survival‑bias, modulate G‑protein coupling geometry, redistribute Ca²⁺ microdomain waveforms, adjust IP₃/DAG signalling topology and recalibrate cAMP–PKA amplitude. Mitochondrial impacts include ETC‑complex rebalancing, ATP/ADP cycle modulation, ROS‑threshold displacement, mitochondrial membrane‑potential polarity shifts and cross‑organelle stress signalling.
High‑Precision Research Applications
- Kinome‑scale interference & catalytic‑cascade modelling
- High‑resolution docking & conformational‑flow prediction
- UPR/ER‑stress & autophagy/mitophagy integration networks
- Full multi‑omics reconstruction (RNA‑seq, proteomics, phosphoproteomics, metabolomics)
- Cytoskeletal force‑mapping & polymer turnover dynamics
- Cell‑fate modelling: apoptosis, necroptosis, ferroptosis, parthanatos
- AI‑driven SAR/QSAR predictive simulation
Toxicodynamics & Cellular Hazard Spectrum
- Excessive ROS accumulation & antioxidant‑buffer collapse
- Mitochondrial fragmentation or ETC suppression
- Hyper‑disruption of Na⁺/K⁺/Ca²⁺ ionic‑gradients
- Cytoskeletal degradation & membrane‑integrity failure
- Inflammatory master‑switch activation (NF‑κB/STAT/IRF)
- Multi‑axis programmed‑cell‑death induction
- Epigenetic drift across methylation & acetylation layers
For expert laboratory research only — not intended for biological use.
Datasheet
| Molecular Formula | C14H20N2O3 |
|---|---|
| Molecular Weight | 264.32 g/mol |
| CAS Number | 149647-78-9 |
| Storage Condition | Store at 20-25 °C (68-77 °F), excursions permitted between 15-30 °C (59-86 °F). |
| Solubility | Slightly soluble in ethanol, isopropanol and acetone; freely soluble in dimethylsulfide; insoluble in methylene chloride |
| Purity | Purity information is available upon request (COA). |
| Synonym | Vorinostat; 149647-78-9; SAHA; suberoylanilide hydroxamic acid; N-hydroxy-N'-phenyloctanediamide |
| IUPAC/Chemical Name | N'-hydroxy-N-phenyloctanediamide |
| InChl Key | WAEXFXRVDQXREF-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18) |
| References |
3D Conformer.
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