VEMURAFENIB
Vemurafenib is a BRAF inhibitor used in metastatic melanoma with BRAF V600E mutations. It blocks MAPK signaling to reduce tumor growth. Side effects include rash, photosensitivity, arthralgia, QT prolongation, and secondary skin tumors. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
VEMURAFENIB exhibits a highdimensional biochemical interaction matrix spanning signallingaxis disruption, catalyticdomain modulation, mitochondrialnetwork recalibration, ionflux redistribution, cytoskeletalarchitecture remodelling, membranepotential rebalancing and transcriptionfactor pathway restructuring. Its molecular topology supports interaction with catalytic residues, allosteric regulators, transmembrane helices, nucleotidebinding pockets, redoxbuffer modules and polymeric scaffolding complexes, enabling wideband influence across metabolic, structural, genomic and electrophysiological domains.
Mechanistically, VEMURAFENIB may reshape phosphorylation maps across ERK/MAPK/JNK/p38 axes, alter PI3KAKT survivalbias, modulate Gprotein coupling geometry, redistribute Ca²⁺ microdomain waveforms, adjust IP/DAG signalling topology and recalibrate cAMPPKA amplitude. Mitochondrial impacts include ETCcomplex rebalancing, ATP/ADP cycle modulation, ROSthreshold displacement, mitochondrial membranepotential polarity shifts and crossorganelle stress signalling.
HighPrecision
- Kinomescale interference & catalyticcascade modelling
- Highresolution docking & conformationalflow prediction
- UPR/ERstress & autophagy/mitophagy integration networks
- Full multiomics reconstruction (RNAseq, proteomics, phosphoproteomics, metabolomics)
- Cytoskeletal forcemapping & polymer turnover dynamics
- Cellfate modelling: apoptosis, necroptosis, ferroptosis, parthanatos
- AIdriven SAR/QSAR predictive simulation
Toxicodynamics & Cellular Hazard Spectrum
- Excessive ROS accumulation & antioxidantbuffer collapse
- Mitochondrial fragmentation or ETC suppression
- Hyperdisruption of Na⁺/K⁺/Ca²⁺ ionicgradients
- Cytoskeletal degradation & membrane-integrity failure
- Inflammatory masterswitch activation (NF-κB/STAT/IRF)
- Multiaxis programmed-cell-death induction
- Epigenetic drift across methylation & acetylation layers
For expert laboratory research only not intended for biological use.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C23H18ClF2N3O3S |
|---|---|
| Molecular Weight | 489.9 g/mol |
| CAS Number | 918504-65-1 |
| Storage Condition | Store at room temperature 20 °C – 25 degC (68 °F – 77 °F); excursions permitted between 15 °C and 30 °C (59 °F and 86 °F), See USP Controlled Room Temperature. Store in the original container with the lid tightly closed. |
| Solubility | <1 mg/mL |
| Purity | Purity information is available upon request (COA). |
| Synonym | Vemurafenib; 918504-65-1; Zelboraf; PLX-4032; PLX 4032 |
| IUPAC/Chemical Name | N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide |
| InChl Key | GPXBXXGIAQBQNI-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) |
| References |
3D Conformer.
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