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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
ONDANSETRON HCL shows a complex, multipathway biochemical interaction profile involving modulation of enzymeregulated catalytic cycles, receptorlevel signalling networks, intracellular ion dynamics, mitochondrial respiratory control, redoxbalance adaptation, cytoskeletal organisation and transcriptionfactor regulatory behaviour. Its physicochemical structure supports direct or indirect interaction with catalytic residues, allosteric pockets, membranespanning receptors, signalling intermediates and structural proteins, enabling influence over secondmessenger pathways (Ca²⁺, cAMP, IP, DAG), phosphorylation kinetics, ROS generation and mitochondrial ATPsynthesis efficiency.
Depending on concentration, exposure duration and biological substrate, ONDANSETRON HCL may shift metabolic routing, alter vesicular transport, influence chromatin accessibility, modify transcriptional clusters, or recalibrate mitochondrial stressresponse thresholds across diverse experimental models.
Benefits and Advantages
Common applications in research environments include:
- Highresolution receptorligand interaction analysis and molecular docking validation
- Enzymekinetic dissection and catalyticpathway reconstruction
- Mitochondrialperformance assays, redoxstress modelling and ATPflux quantification
- Multiomics integration: transcriptomics, metabolomics, proteomics, phosphoproteomics
- Cytoskeletaldynamics studies involving actin, tubulin and membranetension regulation
- Apoptosis, autophagy, necroptosis, ferroptosis and stressresponse pathway mapping
- SAR (structureactivity relationship) investigation and molecularoptimisation workflows
- Preclinical pharmacodynamic modelling and mechanistic doseresponse assays
Side Effects and Risks
Potential laboratoryobserved risks include:
- ROS accumulation and oxidativestress imbalance
- Mitochondrial hyperactivation or respiratorychain suppression
- Disruption of Ca²⁺/Na⁺/K⁺ ionic homeostasis and ionchannel behaviour
- Unintended receptor crossactivation or inhibitory interference
- Cytoarchitectural destabilisation, membrane fragility or impaired trafficking
- Dosedependent cytotoxicity and activation of apoptosis/autophagy signalling
- Transcriptional and epigenetic instability under prolonged exposure
- Inflammatory pathway activation (NF-κB, MAPK, JNK)
Use exclusively under controlled laboratory conditions, following strict biosafety and handling protocols.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C18H20ClN3O |
|---|---|
| Molecular Weight | 329.8 g/mol |
| CAS Number | 99614-01-4 |
| Storage Condition | Store upright between 15 deg and 30 °C (59 deg and 86 °F). Protect from light. Store bottles upright in cartons. |
| Solubility | 47.7 [ug/mL] (The mean of the results at pH 7.4) |
| Purity | Purity information is available upon request (COA). |
| Synonym | ONDANSETRON HYDROCHLORIDE; 99614-01-4; ONDANSETRON HCl; Ondemet; Zophren |
| IUPAC/Chemical Name | 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one;hydrochloride |
| InChl Key | MKBLHFILKIKSQM-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H19N3O.ClH/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H |
| References |
3D Conformer.
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