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Product Description
Mechanism of Action
ONDANSETRON HCL (ID 26955) shows a complex, multi‑pathway biochemical interaction profile involving modulation of enzyme‑regulated catalytic cycles, receptor‑level signalling networks, intracellular ion dynamics, mitochondrial respiratory control, redox‑balance adaptation, cytoskeletal organisation and transcription‑factor regulatory behaviour. Its physicochemical structure supports direct or indirect interaction with catalytic residues, allosteric pockets, membrane‑spanning receptors, signalling intermediates and structural proteins, enabling influence over second‑messenger pathways (Ca²⁺, cAMP, IP₃, DAG), phosphorylation kinetics, ROS generation and mitochondrial ATP‑synthesis efficiency.
Depending on concentration, exposure duration and biological substrate, ONDANSETRON HCL may shift metabolic routing, alter vesicular transport, influence chromatin accessibility, modify transcriptional clusters, or recalibrate mitochondrial stress‑response thresholds across diverse experimental models.
Benefits and Advantages
Common applications in research environments include:
- High‑resolution receptor–ligand interaction analysis and molecular docking validation
- Enzyme‑kinetic dissection and catalytic‑pathway reconstruction
- Mitochondrial‑performance assays, redox‑stress modelling and ATP‑flux quantification
- Multi‑omics integration: transcriptomics, metabolomics, proteomics, phosphoproteomics
- Cytoskeletal‑dynamics studies involving actin, tubulin and membrane‑tension regulation
- Apoptosis, autophagy, necroptosis, ferroptosis and stress‑response pathway mapping
- SAR (structure–activity relationship) investigation and molecular‑optimisation workflows
- Preclinical pharmacodynamic modelling and mechanistic dose‑response assays
Side Effects and Risks
Potential laboratory‑observed risks include:
- ROS accumulation and oxidative‑stress imbalance
- Mitochondrial hyperactivation or respiratory‑chain suppression
- Disruption of Ca²⁺/Na⁺/K⁺ ionic homeostasis and ion‑channel behaviour
- Unintended receptor cross‑activation or inhibitory interference
- Cyto‑architectural destabilisation, membrane fragility or impaired trafficking
- Dose‑dependent cytotoxicity and activation of apoptosis/autophagy signalling
- Transcriptional and epigenetic instability under prolonged exposure
- Inflammatory pathway activation (NF‑κB, MAPK, JNK)
Use exclusively under controlled laboratory conditions, following strict biosafety and handling protocols.
Datasheet
| Molecular Formula | C18H20ClN3O |
|---|---|
| Molecular Weight | 329.8 g/mol |
| CAS Number | 99614-01-4 |
| Storage Condition | Store upright between 15 deg and 30 °C (59 deg and 86 °F). Protect from light. Store bottles upright in cartons. |
| Solubility | 47.7 [ug/mL] (The mean of the results at pH 7.4) |
| Purity | Purity information is available upon request (COA). |
| Synonym | ONDANSETRON HYDROCHLORIDE; 99614-01-4; ONDANSETRON HCl; Ondemet; Zophren |
| IUPAC/Chemical Name | 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one;hydrochloride |
| InChl Key | MKBLHFILKIKSQM-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H19N3O.ClH/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H |
| References |
3D Conformer.
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