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Product Description
Mechanism of Action
Enasidenib mesylate is a selective inhibitor of mutant isocitrate dehydrogenase‑2 (IDH2). Mutant IDH2 converts α‑ketoglutarate to 2‑hydroxyglutarate (2‑HG), an oncometabolite that blocks cell differentiation. Enasidenib reduces 2‑HG levels, restoring normal differentiation pathways.
Benefits and Advantages
Used in IDH‑mutation research, metabolic‑oncology modelling, differentiation‑restoration assays, and epigenetic‑reprogramming studies.
Side Effects and Risks
Risks include differentiation syndrome, hyperbilirubinemia, leukocytosis, diarrhea and fatigue. Handle with targeted‑oncology‑drug precautions.
Datasheet
| Molecular Formula | C15H14N8O·CH4O3S |
|---|---|
| Molecular Weight | 569.5 g/mol |
| CAS Number | 1650550-25-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Enasidenib mesylate; 1650550-25-6; AG-221 mesylate; Enasidenib mesilate; Enasidenib methanesulfonate |
| IUPAC/Chemical Name | methanesulfonic acid;2-methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol |
| InChl Key | ORZHZQZYWXEDDL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C19H17F6N7O.CH4O3S/c1-17(2,33)9-27-15-30-14(11-4-3-5-12(29-11)18(20,21)22)31-16(32-15)28-10-6-7-26-13(8-10)19(23,24)25;1-5(2,3)4/h3-8,33H,9H2,1-2H3,(H2,26,27,28,30,31,32);1H3,(H,2,3,4) |
| References |
3D Conformer.
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