About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Chlorambucil is a nitrogenmustard alkylating agent that forms covalent bonds with DNA, producing interstrand and intrastrand crosslinks. This disrupts replication, transcription and cellcycle progression, ultimately inducing apoptosis. Its ability to target rapidly proliferating lymphoid tissue makes it effective in hematologic malignancy research.
Benefits and Advantages
Used in oncology research, DNAalkylation pathway modelling, apoptosis signalling studies, lymphoidcancer mechanistic exploration, drugresistance evaluations and structureactivity optimisation of alkylating agents.
Side Effects and Risks
Risks include severe myelosuppression, hepatotoxicity, infertility, secondary malignancy risk and immunosuppression. Handle with full cytotoxicagent containment.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C14H19Cl2NO2 |
|---|---|
| Molecular Weight | 304.2 g/mol |
| CAS Number | 305-03-3 |
| Storage Condition | Store in a refrigerator, 2 to 8 °C (36 to 46 °F). |
| Solubility | less than 0.1 mg/mL at 72 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | chlorambucil; 305-03-3; Ambochlorin; Leukeran; Chloroambucil |
| IUPAC/Chemical Name | 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid |
| InChl Key | JCKYGMPEJWAADB-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19) |
| References |
3D Conformer.
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