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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Cabazitaxel is a semisynthetic taxane that stabilises microtubules by binding to β-tubulin and preventing their depolymerisation. This disrupts mitotic spindle formation, halting cell division and inducing apoptosis. Compared with earlier taxanes, cabazitaxel is less susceptible to efflux by P-glycoprotein, enhancing activity in resistant tumour lines.
Benefits and advantages
Used in oncology research, microtubule-dynamics studies, drug-resistance modelling, taxane SAR analysis, apoptosis-pathway research and metastatic cancer mechanism studies.
Side effects and risks
Risks include severe neutropenia, peripheral neuropathy, diarrhoea, hypersensitivity reactions and hepatotoxicity. Handle under cytotoxic-agent containment conditions.
Datasheet
| Molecular Formula | C45H57NO14 |
|---|---|
| Molecular Weight | 835.9 g/mol |
| CAS Number | 183133-96-2 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | CABAZITAXEL; 183133-96-2; Jevtana; Taxoid XRP6258; Xrp6258 |
| IUPAC/Chemical Name | [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1-hydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate |
| InChl Key | BMQGVNUXMIRLCK-OAGWZNDDSA-N |
| InChl Code | InChI=1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1 |
| References |
3D Conformer.
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