BRENTUXIMAB VEDOTIN
Brentuximab vedotin is an antibodydrug conjugate targeting CD30expressing cells, delivering a cytotoxic payload. Used in Hodgkin lymphoma and ALCL, it improves remission rates. Side effects include neuropathy, neutropenia, infections, and infusion reactions. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Brentuximab vedotin is an antibodydrug conjugate (ADC) composed of an antiCD30 monoclonal antibody linked to monomethyl auristatin E (MMAE). After CD30 binding, the ADC is internalised and MMAE is released, disrupting microtubule formation, triggering G/M cellcycle arrest and inducing apoptosis.
Benefits and advantages
Critical in targetedtherapy research, lymphoma biology, ADCmechanism modelling, microtubuledisruption studies, tumourselective drugdelivery investigations and immunooncology development.
Side effects and risks
Risks include peripheral neuropathy, neutropenia, infusion reactions, hepatotoxicity and serious infections. Handle under biologic/cytotoxic dualcontainment requirements.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Weight | g/mol |
|---|---|
| CAS Number | 914088-09-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| IUPAC/Chemical Name | Antibodydrug conjugate (antiCD30 monoclonal antibody + MMAE) |
| References |
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