AFATINIB
Afatinib is an irreversible tyrosine kinase inhibitor targeting EGFR, HER2, and HER4, used in non‑small‑cell lung cancer with specific mutations. Benefits include potent inhibition of tumor growth and improved progression‑free survival. Risks include diarrhea, rash, stomatitis, and rare severe skin reactions, requiring close monitoring.
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Product Description
Mechanism of action
AFATINIB is a pharmacologically active compound used in specialised medical or biochemical applications. Its mechanism of action involves modulation of specific cellular pathways, receptor interactions or enzyme systems depending on its structural class. In professional environments it is applied to influence defined metabolic, neurological, endocrine or immunological processes.
Benefits and advantages
AFATINIB is valued for its predictable biochemical behaviour, defined purity profile and suitability for advanced formulation or research use. It provides targeted activity relevant to its therapeutic or analytical category, offering consistent performance under controlled conditions. The compound is often incorporated into protocols requiring high specificity or reproducibility.
Side effects and risks
Potential risks depend on the pharmacological class of AFATINIB. These may include organ‑specific toxicity, allergic reactions, metabolic disturbances or interactions with other active substances. Because potency and toxicity can vary, handling and use are strictly limited to trained professionals operating within regulated laboratory or manufacturing settings.
Datasheet
| Molecular Formula | C24H25ClFN5O3 |
|---|---|
| Molecular Weight | 485.9 g/mol |
| CAS Number | 850140-72-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Afatinib; 850140-72-6; BIBW2992; Tomtovok; BIBW 2992 |
| IUPAC/Chemical Name | (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide |
| InChl Key | ULXXDDBFHOBEHA-CWDCEQMOSA-N |
| InChl Code | InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1 |
| References |
3D Conformer.
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