AMAROGENTINE
Amarogentin is a bitter secoiridoid compound with digestivestimulating and antiinflammatory properties. Benefits include enhanced appetite and digestive function. Side effects are rare but may include stomach discomfort. Only GMP materials will be supplied, logistics all according to GDP.
About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Amarogentine is a highly bitter secoiridoid glycoside found in gentian species. It stimulates bitter taste receptors (T2Rs) on the tongue and in the upper gastrointestinal tract. Activation of these receptors triggers neural reflexes that enhance salivary, gastric and biliary secretions and may influence appetite and digestive motility.
Benefits and advantages
Amarogentine is used primarily as a standard bitter principle in pharmaceutical and nutraceutical formulations, and as a reference substance in sensory evaluation and bitterness-testing systems. In traditional and modern phytotherapy, amarogentine-containing extracts are employed as digestive tonics to support appetite and gastric function in cases of dyspepsia or reduced digestive capacity.
Side effects and risks
At typical bitter-dose levels, adverse effects are uncommon but may include gastric discomfort or nausea in sensitive individuals. Very high doses could potentially exacerbate acid-related disorders such as peptic ulcer disease. Because amarogentine is intensely bitter, care must be taken in handling and formulation to avoid contamination of other products and to ensure acceptable palatability profiles.
Professional use only. Supplied exclusively to licensed manufacturers, laboratories and institutions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C29H30O13 |
|---|---|
| Molecular Weight | 586.5 g/mol |
| CAS Number | 21018-84-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Amarogentin; 21018-84-8; 5L82GT5I0W; DTXSID501029787; [(2S,3R,4S,5S,6R)-2-[[(3S,4R,4aS)-4-ethenyl-8-oxo-4,4a,5,6-tetrahydro-3H-pyrano[3,4-c]pyran-3-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl] 2,4-dihydroxy-6-(3-hydroxyphenyl)benzoate |
| IUPAC/Chemical Name | Bitter secoiridoid glycoside |
| InChl Key | ZNECFYBFMOKWKH-UTQWQCRQSA-N |
| InChl Code | InChI=1S/C29H30O13/c1-2-16-17-6-7-38-26(36)19(17)12-39-28(16)42-29-25(24(35)23(34)21(11-30)40-29)41-27(37)22-18(9-15(32)10-20(22)33)13-4-3-5-14(31)8-13/h2-5,8-10,12,16-17,21,23-25,28-35H,1,6-7,11H2/t16-,17+,21-,23-,24+,25-,28+,29+/m1/s1 |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
