ACONITINE
Aconitine is a highly potent alkaloid that activates voltage-gated sodium channels, leading to persistent depolarization and severe neurocardiac toxicity. Historically used in traditional medicine, it is now primarily of toxicological interest. While it may exhibit analgesic properties at extremely low doses, risks include arrhythmias, hypotension, paresthesia, and fatal cardiac events, making clinical use unsafe without stringent controls.
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Product Description
Mechanism of action
Aconitine is one of the most potent diterpenoid alkaloids from Aconitum species. It binds to site 2 on voltage‑gated sodium channels, causing persistent activation, prolonged sodium influx and delayed repolarisation. This leads to severe disturbances in nerve and cardiac conduction.
Benefits and advantages
Because of its high potency, aconitine is used almost exclusively as a reference toxin in pharmacological and toxicological research on sodium channels and arrhythmogenesis. It has historical relevance in herbal medicine but is no longer considered safe for therapeutic use.
Side effects and risks
Even small amounts can cause numbness, tingling, nausea, vomiting, hypotension, ventricular arrhythmias and sudden death. There is no specific antidote, and management is primarily supportive. Industrial or laboratory handling requires the highest level of caution, including closed systems and appropriate personal protective equipment.
Professional use only. Supplied solely to qualified research institutions.
Datasheet
| Molecular Formula | C34H47NO11 |
|---|---|
| Molecular Weight | 645.7 g/mol |
| CAS Number | 302-27-2 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | aconitine; 302-27-2; Acetylbenzoylaconine; Aconitinum; CHEBI:2430 |
| IUPAC/Chemical Name | [(1S,2R,3R,4R,5R,6S,7S,8R,9R,13R,14R,16S,17S,18R)-8-acetyloxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate |
| InChl Key | XFSBVAOIAHNAPC-XTHSEXKGSA-N |
| InChl Code | InChI=1S/C34H47NO11/c1-7-35-15-31(16-41-3)20(37)13-21(42-4)33-19-14-32(40)28(45-30(39)18-11-9-8-10-12-18)22(19)34(46-17(2)36,27(38)29(32)44-6)23(26(33)35)24(43-5)25(31)33/h8-12,19-29,37-38,40H,7,13-16H2,1-6H3/t19-,20-,21+,22-,23+,24+,25-,26?,27+,28-,29+,31+,32-,33+,34-/m1/s1 |
| References |
3D Conformer.
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