ACONINE
Aconine is an alkaloid derived from Aconitum species and exerts its effects by modulating voltage-gated sodium channels. It has been studied for analgesic and anti-inflammatory properties but also carries inherent toxic potential. Benefits include potential pain modulation. Side effects may include numbness, cardiovascular irregularities, and neurological symptoms, requiring extreme caution and controlled handling due to narrow safety margins.
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Product Description
Mechanism of action
Aconine is a diterpenoid alkaloid found in plants of the genus Aconitum. It exerts complex actions on voltage‑ gated sodium channels in excitable membranes, initially causing persistent activation and increased sodium influx followed by impaired conduction. This results in marked cardiotoxic and neurotoxic effects.
Benefits and advantages
Aconine is primarily of interest as a research compound for the study of sodium channel pharmacology and plant alkaloid toxicology. It has historically been a component of traditional herbal preparations, though its narrow safety margin has limited therapeutic use.
Side effects and risks
Exposure to aconine can cause paraesthesia, gastrointestinal symptoms, hypotension, arrhythmias, ventricular tachycardia and fibrillation, which may be fatal. Because of its extreme toxicity, use is restricted to specialised laboratory settings with rigorous safety controls, and it is unsuitable for routine therapeutic applications.
Professional use only. Handling is restricted to licensed laboratories with appropriate hazard‑control measures.
Datasheet
| Molecular Formula | C25H41NO9 |
|---|---|
| Molecular Weight | 499.6 g/mol |
| CAS Number | 509-20-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Aconine; 509-20-6; Jesaconine; CHEBI:132639; DTXSID501026571 |
| IUPAC/Chemical Name | (1S,2R,3R,4R,5R,6S,7S,8R,9R,13R,14R,16S,17S,18R)-11-ethyl-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecane-4,5,7,8,14-pentol |
| InChl Key | SQMGCPHFHQGPIF-JIOYIOPFSA-N |
| InChl Code | InChI=1S/C25H41NO9/c1-6-26-9-22(10-32-2)12(27)7-13(33-3)24-11-8-23(30)19(28)14(11)25(31,20(29)21(23)35-5)15(18(24)26)16(34-4)17(22)24/h11-21,27-31H,6-10H2,1-5H3/t11-,12-,13+,14-,15+,16+,17-,18?,19-,20+,21+,22+,23-,24+,25-/m1/s1 |
| References |
3D Conformer.
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